Iodomethane-d3 CAS 865-50-9

Iodomethane-d3 is a colorless liquid, which can be used as isotope labeling reagent. It is a useful research chemical, which is used in biochemical research to analyze peptides and glycans by analytical spectroscopy. Deuterated amino acids have the same structure and similar properties with common amino acids. Deuterated amino acids can be widely used as tracers and internal standards. In clinical medicine, deuterated amino acids can be used to study some physiological mechanisms of human beings, animals, plants and microorganisms, and to reveal the physical and chemical processes in biological cells. Therefore, it is very necessary to study a synthetic method of s- (methyl D3) homocysteine doped with high level deuterium. Deuterated iodomethane is a good deuterium methylation reagent, which is usually synthesized by iodomethane. However, the traditional preparation method of deuterated iodomethane is complicated, the cheap iodized raw materials are in short supply, and the atomic economy is not high.

IODOMETHANE-D3 (methyldeuterium iodide) has a wide range of applications in the laboratory.

1. Labeling reagent: It can be used as a labeling reagent to label hydrogen atoms in compounds. Due to its presence of deuterium isotopes, compounds labeled with it can be more easily detected and identified through mass spectrometry and other techniques compared to naturally abundant hydrogen isotopes (with a relative abundance of 0.0156% deuterium isotopes).

2. Reference standard substance for nuclear magnetic resonance (NMR): Due to the clear signal of product in the NMR spectrum, it is commonly used as a reference standard substance for deuterium spectroscopy (2H NMR). The characteristic chemical shift signal can be used to calibrate the sample solvent and analyze and identify the NMR spectra of other compounds.

3. Reaction reagent: it can be used as a reaction reagent in synthetic chemistry. It can react with alkali metals, boron alcohols, haloalkanes, etc. to generate compounds with deuterium labels. These labeled compounds can be used to study reaction mechanisms, track reaction pathways, and analyze and characterize the properties of compounds.

4. Solvent: it can be used as an inert solvent, especially suitable for certain high sensitivity experiments. Due to the weak interactions between carbon deuterium bonds and iodine deuterium bonds with many chemical reagents, it can provide a highly inert solvent environment in certain chemical reactions.

5. Methane source: it can be used as a source of methane. Under certain laboratory conditions, it can generate methane (CH4) by reacting with reducing agents such as sodium borohydride. This method can be used to prepare deuterium (D) or tritium (T) labeled methane for research or other experimental needs.

Iodomethane-d3 Researched by: BLOOM TECH

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Most deuterated iodomethane is prepared through the iodization reaction of deuterated methanol, and different synthesis methods can be used depending on the type of iodization reagent.

Method 1:

Slowly inject red phosphorus reagent (50.0 g, 1.6 mol), H2O (100 mL), and elemental iodine (250.0 g, 1.0 mol) into a dry 250 mL flask with a reflux condenser at -15 ° C for 0.5 hours. Then gradually add deuterated methanol (30.0 grams, 0.8 moles) to the reaction mixture. Heat the reaction mixture to 65 ℃ and continue stirring for about 2 hours. After the reaction, cool the reaction mixture to room temperature. Finally, distill the reaction mixture at 45 ℃ and collect the corresponding fractions to obtain the target product molecule D3 iodomethane.

Method 2:

Add deuterated methanol (CD3OD) (0.5 g, 1.13 mL, 0.0138 mol) to dry dichloromethane (10 mL) in a 20 mL round bottom flask. Then add TMSI (2.77 grams, 1.98 milliliters, 0.0138 moles) to the obtained reaction solution, and slowly stir the reaction mixture at 0 ℃ for several hours. Then transfer it to room temperature and stir the reaction mixture at room temperature for 8 hours. After the reaction is completed, there is no need for further purification. The deuterated iodomethane obtained from the reaction can be directly used for the next step of the reaction.

It is a colorless liquid and can be used as an isotope labeling reagent. It is a useful research chemical. Uses Iodomethane-d3 CAS 865-50-9 is used in biochemical research to analyze peptides and glycans by applying analytical spectroscopy techniques. Please refer our enterprise standard or COA, if you need to negotiate, welcome to consult our sales. Welcome inquire! Our sales Dept. will provide the one-for-one service for you, including business and technology support. Addition information of chemical compound: MP - 66.5 ° C (lit.), BP 42 ° C (lit.), Density 2.330 g / ml at 25 ° C, Vapor density 4.89 (vs air), Vapor pressure 22.83 psi (55 ° C), Refractive index N20 / D 1.5262 (lit.), Storage conditions: 0-6 ° C, Form liquid Color clear colorless, BRN 1732026.

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