Click on the image to check the artwork
By certification 
Tetravisc CAS 94-24-6. In addition, it is also another name for tetracaine, tetrakaine, pontocaine. Tetracaine (Tetravisc ) will decompose under oxidative heating, producing CO2 and nitrides. The initial decomposition temperature is 285 ° C. It is prone to decomposition due to environmental factors such as air, light, heat, and humidity, so it is necessary to pay attention to maintenance during storage and use. The metabolism speed in the body is slow and will accumulate in the body. Long term use of large doses may cause hepatotoxicity or neurotoxicity. The maximum tolerable concentration is 0.5%. After absorption through the skin and mucous membranes, it will undergo metabolism and exert its effects in the body. The effective period is 2-4 hours. Overall, Tetracaine is a local anesthetic with poor stability, so caution and compliance with relevant safety regulations are necessary during use.
Pharmacological properties:
1. Anesthetic effect: The main function of Tetravisc is to inhibit the conduction function of nerve fibers at nerve endings, achieving anesthesia, pain relief, and reducing reflexivity.
2. Vasodilatory effect: Tetracaine can produce vasodilation by inhibiting the synthesis of angiotensin, thereby lowering blood pressure and reducing cardiac load.
3. Antibacterial effect: Tetracaine has a certain antibacterial effect at a certain dosage and is effective against certain bacteria, fungi, and viruses.
Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us. Our dedicated scientific research personnel study the most effective synthetic circuit of products. The product circuit in the figure below is the circuit of customized products previously accepted by our company. If you have customized needs, you can send the products you need to our scientific research team for research and development.Â
Synthesis method catalyzed by polytetrafluoroethylene:
Recently, someone reported a catalytic method for directly synthesizing Tetravisc . The key to this method is to use polytetrafluoroethylene as a catalyst to react 2- (4-aminobenzyl) phenol with benzoyl chloride and isopropyl carbamate. Tetracaine with a yield of over 90% can be obtained within 3 hours. The advantage of this method lies in its simple steps, high yield, and fast speed, which can effectively reduce costs.
Synthesis of Tetracaine by Hydrogenation Reduction Method, the specific steps are as follows:
(1) React 2-acetoamino 4-methylphenol with 3-acryloyl chloride in chloroform to obtain 3- (2-acetoamino 4-methylphenoxy) propionyl chloride.
(2) The above product and 2-propenyl-N-phenylformamide are heated and reacted in the presence of hydrochloric acid to obtain 3 - (2-N-benzoyl-2-propenylamino-4-methylphenoxy) propionyl chloride.
(3) The above products were hydrogenated and reduced with aluminum oxide magnesium complex and lead acetic acid in the presence of isopropanol to obtain Tetracaine.
People allergic to this product are not allowed. People with severe allergic constitution should not be allowed. Cardiac, renal insufficiency, myasthenia gravis and other patients are contraindication. Infiltration of local anesthesia, intravenous injection and intravenous drip are contraindication.
The local anesthetic effect of Tetracaine is achieved by interrupting the transmission of nerve impulses. A nerve impulse is an electrical signal that travels along a neuron's axon. The sodium channel on the axon is normally open. When a nerve impulse occurs, sodium ions pass through the channel, resulting in a change in the potential difference between the inside and outside of the cell, which in turn leads to the transmission of the nerve impulse. When a nerve impulse reaches a nerve synapse, it releases some chemical signals, called neurotransmitters, that interact with the sodium channel of the next neuron, which continues to transmit the nerve impulse. Tetracaine interrupts the transmission of nerve impulses by selectively inhibiting sodium ion channels, thereby producing a local anesthetic effect.
http://www.bloomtechz.com/
